For example, if you're trying to optimize a mailbox server, you want to put your database transaction log files (not to be confused with message tracking log files) on a separate set of spindles (i.e., ideally a RAID1 set), your binaries on another set of spindles (i.e., RAID1), your pagefile on another disk (no RAID), and finally your databases on another set of spindles (i.e., ideally a RAID0+1 set).
If you're optimizing a high volume SMTP gateway, you want to make sure the mailroot directory (<drive>: \Program Files\Exchsrvr \Mailroot) is spread across as many spindles
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