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It's regrettable that you have to fix this issue by restarting IIS. You shouldn't have to do that. Have you checked for memory leaks in inetinfo.exe? You might also try taking a network capture using Network Monitor during the time at which this problem manifests itself.
I also strongly recommend moving to the latest service packs for both Windows 2000 and Exchange. These include all necessary security updates and critical updates from Windows Update.
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