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There is a lot involved with your question. I would strongly recommend you download and read the Microsoft white paper "Using Microsoft Exchange 2000 front-end servers." This will give you background on front-end and back-end servers and pros and cons for various scenarios that apply to your particular environment.
Do you have comments on this Ask the Expert Q&A? Let us know.
Related information from SearchExchange.com:
Tutorial: How to set up a front-end Exchange Server cluster
Crash Course: Exchange 2003 cluster configuration
Expert Advice: Decide between a front-end and a back-end Exchange server
Tip: Best practices for Exchange server clustering
Reference Center: Exchange clustering tips and tutorials
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