EXPERT RESPONSE
You can perform the Exchange 2003 offline defragmentation during your next maintenance window. You won't corrupt the Exchange database, so whether you run the offline defragmentation or not is really a matter of preference. Assuming you have adequate room on both drives, it really doesn't matter when you do the Exchange database file move.
You definitely should NOT rename these files.
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Related information from SearchExchange.com:
Tip: Is an offline defragmentation really worth it?
Tip: Exchange Server storage sizing and location best practices
Expert Advice: Running ESEUTIL to compact an information store
Reference Center: Exchange Server defragmentation tips and resources
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