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The best way to "block" messages is to implement a solid antispam solution. Exchange's Intelligent Message Filter (IMF) should be enabled at a minimum. You can also look at supplementing IMF with a connection filter. Connection filters allow you to subscribe to block lists (also known as Real-time Blackhole Lists or RBLs). You can also create your own Global Accept and Global Deny lists.
Third-party RBL providers include the Distributed Server Blackhole List (DSBL) and Mail Abuse Prevention System (MAPS).
There are always a variety of third-party software and hardware solutions that you can obtain that are equally as effective and come with more bells and whistles.
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Related information from SearchExchange.com:
Learning Guide: How to fight spam on Exchange Server
Crash Course: Exchange Intelligent Message Filter
Tip: Configure an Edge Transport server to filter spam
Tutorial: How to protect Exchange Server from spam blacklists
Reference Center: Antispam software and spam filtering resources
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