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VIEW MEMBER FEEDBACK TO THIS ASK THE EXPERT Q&A.
Sue Mosher, Microsoft Outlook MVP, provides a registry key that you can use to disable the use of .PST files. Create or modify the following DWORD registry value:
HKEY_LOCAL_MACHINE\Software\Microsoft\Office\11.0\Outlook\DisablePST. Set the value to 1 to disable .PST files, or 0 (default) to enable them.
Note that .PST files that are already in a user's email profile will still be able to function. Therefore, you should manually remove all .PST files from the profile prior to setting this value. This also includes disabling the auto-archiving feature, which takes advantage of .PST files.
Sue's article can be found here.
MEMBER FEEDBACK TO THIS ASK THE EXPERT Q&A:
Your advice on how to disable .PST files in Microsoft Outlook 2003 prevents new .PST files from being created with the "File -> New -> Outlook Data File" method, but I believe you can still create them with the "Tools -> Email Accounts -> New Outlook Data File" method. Is there a way to turn this off, as well?"
Gerald B.
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One possible solution is to install the Outlook group policy template, and then configure the option to disable end-user access to "Tools > Email Accounts." See the screenshot below for a sample.

Brad Dinerman, Clients and Mobility expert
Do you have comments on this Ask the Expert Q&A? Let us know.
Related information from SearchExchange.com:
Learning Center: A primer on Exchange .PST files
Expert Advice: How to hide users' .PST files
Expert Advice: Access .PST files through Outlook Web Access
Reference Center: .PST tips and resources
Reference Center: Microsoft Outlook tips and resources
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