I'm unaware of any built-in Exchange server functionality that enables you to do this. It may be possible to automate sending OOF from a dedicated client (with a profile) scripting or on the server with Collaborative Data Objects (CDO), Exchange 2000 and below.
MEMBER FEEDBACK TO THIS ASK THE EXPERT Q&A:
I'm not sure what the asker means by "without a profile, etc.," but Out of Office can be set up through Outlook Web Access on the Exchange server.
—Philip M.
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It is possible to do this via Outlook Web Access, which does not require either Outlook or profiles?
—David W.
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We do it via OWA client, which saves us from having to set up a profile.
—Jenny H.
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OWA can be used to set up Out of Office replies.
—Michael B.
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