Microsoft Exchange 2013 Poison Message Queue is a queue that exists specifically to hold messages deemed harmful after a transport server or service failure.
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Also available in Exchange 2007 and Exchange 2010, the Poison Message Queue essentially acts as a quarantine, as it identifies and holds messages that Exchange 2013 has determined detrimental to the environment. The messages may actually be harmful, or they may be flagged due to an incorrectly written agent that caused a failure when Exchange 2013 mail flow tried to process the message.
Messages in the Poison Message Queue do not leave the queue -- and do not expire -- unless the Exchange administrator moves them manually.