I am fully aware that both Exchange and SQL Server should never share the same box, as they both grab all the resources possible. But can you explain to me why none of these applications/systems should be on the same server?
To add insult to injury, no limitations were set on e-mail profiles and some are extreme.
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End-users are generally unwilling to wait for RPC responses from Exchange, or wait for complex queries to complete against SQL Server. This means you should always plan on isolating these applications, or understanding through the use of Perfmon and WMI the end-user experience you are providing.
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This was first published in October 2005

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