You've likely hit your mailbox quota specified in Exchange Server. On the BlackBerry mobile device, click Email...
Options -> Email Reconciliation -> Purge Deleted Items.
This problem can also be caused by the Exchange update that prevents members of the domain admin group from having the 'Send To' permission. Since this permission is removed, the BlackBerry server can not send email, on behalf of a user, if they are in the domain admin group. A user who needs domain administrator rights should be placed in the administrators group and not the domain admin group.
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