You should be using an Exchange-aware backup solution to back up your Exchange server, so you should not have to go in at this level (or the transaction log file level) to do file-level backup of your Exchange Server. This is risky and not recommended.
An Exchange-aware backup will allow you to select the appropriate databases and mailboxes) that you want backed up on any given server. They will then back them up.
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This was first published in December 2009