- Separate set of spindles for each database.
- Separate set of spindles for each set of transaction log files.
- Separate set of spindles for binaries and other data.
You may also want to look at putting your operating system paging file on a separate set of spindles if you have the resources.
In the end, it all depends on the load you expect this server to process the kind of client usage (i.e., Outlook Web Access vs. Outlook vs. POP/IMAP), and the server role (i.e., bridgehead, mailbox, public folder, etc.).
There is nothing technical in Exchange that mandates these sets of spindles; it's really all about performance. You can run an Exchange server with one set of spindles but it will be slow, so I don't recommend it.
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