- Separate set of spindles for each database.
- Separate set of spindles for each set of transaction log files.
- Separate set of spindles for binaries and other data.
You may also want to look at putting your operating system paging file on a separate set of spindles if you have...
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In the end, it all depends on the load you expect this server to process the kind of client usage (i.e., Outlook Web Access vs. Outlook vs. POP/IMAP), and the server role (i.e., bridgehead, mailbox, public folder, etc.).
There is nothing technical in Exchange that mandates these sets of spindles; it's really all about performance. You can run an Exchange server with one set of spindles but it will be slow, so I don't recommend it.
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