It's hard to say. How much memory is in there? How much disk space? What else is running on this server? How would you categorize your user -- light, medium or heavy usage? What type of access-MAPI, POP3, OWA, IMAP4? Go get a copy of the Exchange 2000 Resource Kit; you'll find a tool called Loadsim that you can use to see how your server will perform under various simulated loads.
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